dogmatixpsych writes "I work in a neuroimaging laboratory. We mainly use OS X but we have computers running Linux and we have colleagues using Linux. Some of the work we do with Magnetic Resonance Images produces files that are upwards of 80GB. Due to HIPAA constraints, IT differences between departments, and the size of files we create, storage on local and portable media is the best option for transporting images between laboratories. What disk file system do Slashdot readers recommend for our external HDDs so that we can readily read and write to them using OS X and Linux? My default is to use HFS+ without journaling but I'm looking to see if there are better suggestions that are reliable, fast, and allow read/write access in OS X and Linux."