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Science

What is Human Growth Hormone? 66

EelBait asks: "I get a lot of spam selling Human Growth Hormone (HGH). Supposedly this stuff builds muscles, make one lose weight, enlarges various external organs and glands, etc., etc. Does anyone really know any good articles about this? Is it dangerous? The fact that it's being sold through spam is enough to give me pause, but I want to know if there are any legitimate uses for this stuff."
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What is Human Growth Hormone?

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  • No (Score:1, Redundant)

    by tswinzig ( 210999 )
    Sorry
  • by sithkhan ( 536425 ) <sithkhan@gmail.com> on Tuesday December 17, 2002 @02:09AM (#4905343)
    I've heard of this website that is AWESOME for websearches. Perhaps you have heard of Google [google.com]. It is SWEET! Try it out! It's cool, it's hip, and all the kewl kids are doing it! Plus it's got a beat you can dance to!
    • It has a beat? Crap. Now I KNOW white boys don't have rhythm.
  • I keep getting spam on it and was curious about it. The fact that I was revceiving spam on it gave me pause, but I figured I'd ask the slashdot crowd about my spam for some reason because PE is an acronym. Geeks like acronyms, don't we?

    Of course this begs the question: Did Cliff just get trolled?

  • by muon1183 ( 587316 ) <(muon1183) (at) (gmail.com)> on Tuesday December 17, 2002 @02:10AM (#4905356) Homepage
    Human Growth Hormone is usually used to treat hormone deficiencies in children. My brother needs to take it by injection daily because he has a thyroid binding deficiency, but he's only 5 years old, and will probably stop taking it before he is 18. While it has been well studied on children, it's effects on adults are nowhere near as well studied. While some people believe it is something of a "fountain of youth," this has yet to be found to be true under any studies, and no long term safety tests have been run on adults. So, the conclusion is that you were right to be mighty suspicious of that spam you keep getting.
    • So, the conclusion is that you were right to be mighty suspicious of that spam you keep getting.

      Really? My God! I always thought that unrequested advertisements featuring fantastical claims sent to me via an anonymous email source were very reliable! Damn! I guess I learned something today!

      GMD

  • It causes the body to basiclly "grow". Once your fully grown, I would guess that it tells your body to basically regenerate. Its becomming a popular drug for parents who think their kids are "too small". I know a guy who started high school at 6'6" thanks to his mom thinking he was too short at 5'4" a year before.
    • Yeah, but you gotta know when to stop. I knew this 40 year old who started taking it and he died of old age six months later. (Regeneration my butt!)

      I can totally see how it helped that kid, but his mom better make sure he gets off it soon. Hormones are, like, powerfull stuff and he could end up accelating his "growth" right past his prime!

      Oh, and I almost forgot, don't give any to your little bother!

      -Derek

    • by Anonymous Coward
      Parents who fuck with their kids growth like this are retarded.

      OK I'm biased, but I'm female and 6'5". By the time I was 12 I was already 6' tall, and my mother's sister was so 'concerned' about the effects of me being tall, she constantly contacted doctors and welfare groups about the need to stop my growth. Most of them told her to piss off, but she was persistent enough that through my childhood it felt like I was being hounded constantly for being unnatural.

      Screw that! I'm tall, I ADORE being tall, and if anyone had messed around with my natural height I'd be pretty damned annoyed at them for taking that from me. If it's the kids decision, all's fair, but this is such a common thing, for parents to take their tall daughters for treatment to stop growth.

      (fwiw it's genetics. My grandfather was over 7' and most of my mother's side are near 6')
    • No regeneration, not exactly...

      You know, some people get in their old age a glandiary deficiency and they start having growth hormones again. What happens is that some parts of their body, especially nose and ears start to grow again...

    • His bones lengthened *14 inches* in 12 months? You're full of it.
      • Not necessarily. My father grew about that amount in 18 months; in some families growth can be achieved in a remarkably short period of time. It can happen in other higher-order vertebrates; why not in humans? It's just another case of genetic variability.

        I also knew of a young man who between 7th grade and 8th grade grew from about 5'4" to 6'6". So even if I didn't have my father's example, there's one.

        Unusual? Yes. Improbable? Yes. Unlikely? No; even in a population of about 350 million it's going to happen at least once and more likely many more times. Get a big enough population sample and pretty much anything is possible, especially with genetics.
  • Uhhh. (Score:5, Funny)

    by orthogonal ( 588627 ) on Tuesday December 17, 2002 @02:27AM (#4905433) Journal
    Human Growth Hormone has some legitimate uses -- in a nutshell, stimulating growth -- if your growth is stunted by lack of. Otherwise, no.

    Besides, I'm sure the HGH being sold by spam is only the pureset, unadulterated, and completely legit you can get. In fact, if you need money to buy it, I'll give you $419,000,000 if you help me get some funds out of Nigeria.
  • by MacAndrew ( 463832 ) on Tuesday December 17, 2002 @02:31AM (#4905446) Homepage
    The application is obviously important to its appropriateness. It sounds like you may be toying with the idea of trying; if so first consult with a doctor. Many things promoted through alternative channels may have additional effects not mentioned by the distributor -- St. John's Wort, for example.

    Check the NIH site for information.

    Also, of course don't buy anything from spam on principle alone!
  • Comment removed (Score:5, Informative)

    by account_deleted ( 4530225 ) on Tuesday December 17, 2002 @02:31AM (#4905449)
    Comment removed based on user account deletion
    • HGH is not a steroid. HGH is not illegal. It is controlled; you need a prescription to get HGH.
    • How did this shit get moderated up?

      Anything good for you is something you most certainly won't feel in a day.

      If you are feeling it in a day, be alarmed. Ultra high doses of caffeine, super saturated sugar and butt load of carbohydrates *will* make you feel better in a day, all the while ignoring or masking the ill effects of ODing on such.

      Yeah, you can OD on sugar and carbos. I won't explain how, because it is so simple to see.

      Effervescent creatine. Hahahahaha. Is that like effervescent RDNA? Ion exchange? HAHAHAHAHA. Oh, yeah, but it is ISOPURE. Beam me up, Scotty.

      He goes on to say that another common method of adding energy is to add dextrose to the mix. Yeah! Hello! Super-sutrated sugar in an 8 ounce can will light up an elephant for a week! Ya, wonder why it spikes your insulin level? Diabetic yet?

      Ha.

      • Re:illegal (Score:3, Insightful)

        by sql*kitten ( 1359 )
        Anything good for you is something you most certainly won't feel in a day.

        If I understand creatine's mechanism correctly, it enables you to train for longer. Essentially, the amount of work (reps at a given weight) to produce an increase in strength remains constant whether or not you use it, but the creatine enables you to do more reps in each training session and recover faster, so the "wall clock" time for an increase in strength is reduced. For example, maybe you could normally do 500 reps of a particular lift in 10 weeks, now you can do them in 5. You still have to do them, tho'.

        So you would see the result in terms of being able to train harder after a very short time (possibly after the first use), altho' obviously actually developing the muscle will still take time. I've never used it myself, and would advise you check with a doctor if you are thinking about it.
      • It got moderated up because it is informative.

        Creatin actually makes you work much harder, in a number of ways, but one of them is by causing water to be retained in the muscle, making each rep expend more energy, and work the muscle harder.

        You will absolutely feel it in one day, especially if you work out regularly, as you're regular work out will wreck you completely.

        As for your comments on the names: Their brand names and brand names never were claimed to be interesting. Penguin Computing? Does that mean it was built by flightless birds in antartica?

        And he's correct about the dextros, and he provides that information with the warning you so gleefully yack off on.

        Go home pasty.

        • Yes but what's bad about the comment is that he uses the GNC-world's pseudo-scientific terms as if they mean something. People with brain cells know that ExoIsoLimboHydroCalifragilisticexpialodociousness doesn't mean jack. The companies that market over the counter drugs to athletes and body builders prey on the fact that many of their are scientifically illiterate (other than what they learned from these drug companies, and from freinds and coaches who learned it from the same, ad infinitum). They hype up pseudo-scientific words and descriptions - and 99% of the time a scientist can show that the claims don't mean jack, or at least mean nothing at all similar to what people usually take them to mean.
    • Amen. HGH is used to treat kids who suffer from growth problems, ie, they have stunted growth due to malformed growth plates or the like. They are typically on it for a relatively short period of time, I thought it was supposed to stop before puberty but I could be mistaken.

      Creatine is great stuff, I used it in college for a couple of months on/off and had a noticable gain (the best measure I can give you is going up 30-40 pounds in my bench press over the course of about 3 months). I used to stack Creatine with Hydroxycut, and I got great results from that. Hydroxycut gave me the energy to work out after a full day behind a computer, and the creatine added the muscle. Don't do it for long, I think 2-3 months is the longest stretch you're supposed to use it and then cycle off for another 2-3.

      Remember, more than anything a healthy diet and workout regimen are the most important parts. If you're taking anything (creatine, andro, hydroxycut...) and not working out or eating crap, you're doing your body a disservice. Good food, LOTS of water and working out are the way to go.

      --trb
    • ... it's not illegal since it's not a hormone that occurs naturally in the human body

      Why would the legal status of a hormone supplement depend on whether or not it occurs naturally in the human body? If it did, I would have thought the dependence should go the other way: if something doesn't occur naturally in the body, it has more reason to be illegal, surely?

    • Thanks for the info. Yours is probably the only post that was anywhere near the mark I was after. Looks like I've done about the same as you: Creatine, lots of protein, weight lifting, moderate cardio. I have not tried anything else, yet, so I was looking for addition info.

      Over the past year, the Creatine helped quite a bit. I went from a 125 lbs geek to 155 lbs at age 35. I decided to start doing something about exercise since I sit at a desk all day. (Hm. I'm posting on /. -- that includes nights too.)

      Judging from everything I've read on HGH, I will be staying far from this stuff.
  • If anecdotal evidence is what you want, AskSlashdot is not the place...well not anecdotal evidence about HGH.

    First, go to a shop that sells supplements. Not a GNC shop. Make sure the guy weighs at least 200lbs, works out regularilly, etc. Build some rapport. Ask him what he has "behind the counter". Then ask about HGH. Ask him about results, side effects, etc. Even if he doesn't use the stuff or sell the stuff, if you're at a knowledgeable shop he'll answer your questions. Make sure that they are smart questions or you'll get squat. (And not a set of squats at a squat rack).

    Then read what the journals such as the New England Journal of medicine have to say about them.

    Then decide where your stupid line is and whether taking HGH crosses your stupid line.

    Then buy the penis enlargement program instead.

    My personal advice is to go to a good gym regularily. If everyone who works out at this gym wears workout gloves, then you're not at a gym you're at a spa. Eat 5-7 healthy meals a day. Go easy on the carbs. Jack up the protein intake from sources like chicken and tuna. Then consider supplements such as protein powders, creatine, glutamine. But make sure you do your research.

    I suspect evangelizing working out to the /. crowd is like evangelizing opensource to MS.

    I'll leave you with some words of wisdom by Rocko from Undergrads [undergrads.tv]: Diets are for chicks. Real men go to the gym

  • This article on about.com [about.com] gives a good overview (it's for children with stunted growth, or pituitary gland problems). According to the article use in adults can cause diabetes and pooling of fluids in tissues, high blood pressure etc.

    It used to be produced by sucking it out of dead people [bbc.co.uk] but now is now synthetically produced due to CJD (human variant of 'Mad Cow' disease) risks-- it comes from the pituitary gland so is high-risk for transferring the disease (possibly!)

    Scientists are now looking at producing HGH from animal semen [nature.com] because "semen is a body fluid that can be collected easily on a continuous basis" ... and in this press release from Nature [nature.com], they "suggest that boars (male pigs), which can produce up to half a liter of semen at a time, could be similarly engineered to produce pharmaceutical proteins both cost-effectively and efficiently"

    !!

    I guess it goes
    1. Get pig
    2. Genetically engineer pig
    3. Find someone to 'milk' half a liter ... "Look Daddy, I'm a farmer!!"
    4. profit!

  • by WolfWithoutAClause ( 162946 ) on Tuesday December 17, 2002 @03:35AM (#4905599) Homepage
    HGH in adults helps build muscles. It's a hormone that is secreted during exercise (and about an hour after you fall asleep) that allows a certain set of proteins into the muscles, these proteins allow hypertrophy and muscle repair to proceed, but only if you've worked out in the last few days, otherwise it does nothing good for you.

    Professional bodybuilders inject it along with steroids and insulin; and it makes you big and strong when used that way, in combination with exercise and eating lots and lots of food. Atleast it does unless the insulin or the steroids kill you first.

    In overdose of HGH causes deformed joints, and atleast one bodybuilder ended up with leukemia that was promoted by his abuse of HGH.

    People with naturally high levels of HGH die young by the way, so it's very probably not a fountain of youth, although it may make you feel stronger and better, but you will probably die earlier.

    Oh yeah, there's a natural way to boost HGH levels. If you've had no protein or carbohydrates for about 5 hours (doesn't work otherwise), 3 grams of arginine on an empty stomach triggers its secretion after about 1/2 an hour. It lasts for about an hour in the body. If after 1/2 an hour you eat some food, it may be very slightly anabolic but minisculy so. That's probably what they are advertising. If so, it's best taken before breakfast. Oh yeah, and taken that way, it's hardly anabolic at all, and probably can still cause the deformed joints if you overdose.

  • by Hungus ( 585181 ) on Tuesday December 17, 2002 @03:53AM (#4905654) Journal
    As others have stated HGH is used to regulate growth during childhood and adolescence and is produced throughout the rest of your life (diminishing with age). Like most horomones, if you have a deficiency then you should be treated, on the other hand in excess it will cause acromegaly (Giantism) as seen in such people as Andre Rene Rousimoff (Andre the Giant) [andrethegiant.com], Hatton, Rondo (the Creeper) [acromegaly.com] Deeter Deerkin (My cousin Richard), Richard Kiel(Jaws from James Bond), [imdb.com] Dick [acromegaly.com] Sutherland [imdb.com] Also by adding a growth factor into your sustem it can trigger the growth of internal organs ( leading to an enlarged heart, or similar situations) and teh growth of tissues you simply don't want to grow - otherwise benign tumors and such I suppose the point is as with any horomone moderation is best ... with moderation being what your body already produces on its own...
  • by GrimSean ( 545405 ) on Tuesday December 17, 2002 @04:44AM (#4905765) Homepage
    As some people have allready mentioned above, Andre the Giant [andrethegiant.com] is a good example of what happens to a person with too much HGH, but what they've failed to mention is that Andre had that problem for his entire life. The condition is called acromegaly [umm.edu] and is caused by an abnormality in the pituitary gland which causes escess amounts of HGH to be produced. Since the HGH was affecting Andre at an early age, it caused his relatively large size (most people suffering from acromegaly reach 'adult' size by age 11 or 12), and ultimately his death (congestive heart failure).

    HGH works by stimulating the growth of cartilage in the Epiphyseal Plate [vt.edu], which causes lengthening of the bone. Unfortunately, once you finish puberty, the epiphyseal plate hardens into the epiphyseal line, which is why you stop growing (if you get an X-ray done on your arm, have the doc point it out to you - it'll be right near the end of the bone, just before it widens at the end).

    In mature people, however, elevated levels of HGH cause the sides of bones to thicken, leading to very heavy features in the face, and wide hands and fingers. This can be seen in pictures of 'Giants' as well - not only are they quite tall, but their hands and faces are quite wide as well.

    Basically, HGH in large amounts is bad for the mature human being. There have been a number of studies on its effects, and the major bad ones include increased incidence of cancer and diabetes. You have to remember that this is a hormone, and hormones basically control our bodies - messing with their balance can have very bad side effects. If you're serious about bulking up, an exercise routine is a much better way to go.

  • Art Bell, the guy with the daily radio show about ufos and ghosts www.artbell.com, says it did wonders for him. MAde him feel like a kid again. It was something he wanted his listeners to know all about, matter of fact he was still raving about it in pre-recorded segments while he was off the air for a few weeks with a hurt back.

  • Hmmmmmmmm, HGH. Sweet taste, some gigantism.
  • Growth Hormone (Score:3, Informative)

    by Big Sean O ( 317186 ) on Tuesday December 17, 2002 @08:11AM (#4906291)
    Human Growth Hormone (HGH) is manufactured in the pituitary and is the primary hormone responsible for growth.

    Giantism and Dwarfism are two conditions that can be caused from too much or too little HGH production. The most common reason for over production of HGH is a tumor on or near the pituitary.

    Although the effects on growing animals are well documented, the effects on grown animals are less understood.

    If I recall my college Endocrinology classes correctly, in children HGH has the most profound effects in long bones in the legs and arms. Long bones grow from the middle of the bones, in regions called growth planes (IIRC). HGH stimulates these growth zones.

    The problem with using it on children is principally the dose. If a child is small and you give it HGH, you will increase it's growth, but you may also end up fusing the growth planes early. Thus the 4'6" boy may grow a whole foot, but finish growing early at 5'6". Once the growth planes fuse, HGH isn't going to do much that is visible.

    Bovine Growth Hormone (BGH) is used to stimulate milk production in dairy cows. However, the public concern about this practice caused Ben & Jerry's to ban the hormone in cows that provide milk to them.

    I would be highly suspect of any HGH preparation you could buy from a spammer over the internet. HGH is a protein, and proteins can degrade during extraction. I recall using hormones in laboratory research and refrigeration was necessary for all our hormones at almost every step. Since the structure of the hormone is the reason it's biologically active, anything that can degrade the structure is a bad thing. A previous writer is also correct. Injection is preferrable to ingestion. Stomach acid does awful things to protein.
  • If you really want to know, ask your doctor. He will be able to tell you what the effects of HGH are, whether or not you can legally obtain it. In most countries, it would be classified as medication and thus subject to several regulations. Ordering this product from a spammer could be illegal.

    If your doctor decides it would have beneficial effects on you and gives you a prescription, use that to obtain it, and not buy from the spammer. After all, you don't know what they will sell you, and when you have already paid, it is too late.

    Whatever you do, do not buy anything from a spammer. (You don't want them to use you as an example to show that "spam works", do you?)

    Personally, I wouldn't believe them. After all, if it really works, would they have to resort to spam to sell it?

  • Wait till someone comes out with a Penile Growth Hormone (PGH), that supposedly will make your penis grow 1 inch per month.
    • Wait till someone comes out with a Penile Growth Hormone (PGH), that supposedly will make your penis grow 1 inch per month. ...until it gets so long it curves around and jams itself up your ass. Ooofff.
  • I'm looking for any possible way to lose weight and look good. Other than eating right and working out, that just SuX0r5.
  • what I know (Score:1, Informative)

    by Anonymous Coward
    Well. I have been involved with, errr, people who know a lot about steroids and the such. And HGH is a big subject. It is not legal in the US, but it can be obtain by mail order (illegal but easily pulled off) or in Mexico/Europe and brought over (illegal as well, but once again it is done daily I would think).
    The stuff is not going to make you grow in height if you are past a certain age, I would think late teens would be the cutoff for most. It will make you gain muscle (if you are working out). All top body-builders use GH, as well as massive amount of steroids, and they are freaks of course. It is sort of holy-water for juicers, but its price seriosuly limits its use. Problems involved can be a lot of things. This stuff causes you to grow. I have seen people have to get braces because their teeth started messing up, a common thing is enlarged thyroid and even heart. Not a lot of research has been done on people at the doses bodybuilders are using it. And its not just bodybuilders. I would say olympic athletes abuse GH heavily because it is pretty much untraceable; the best they could do would be test your HGH level, but if you have been off just a few days it would have returned to baseline or less. Actually, sheesh, whats her name, the sprinter-lady with long finger nails, she had thyroid problems because of GH use.
    It does not increase penis size, as that doesn't really have anything to do with "growing" in the HGH sense.
    I have not tried HGH because it is extrememly expensive, and to use it adequately you have to inject frequently (at least 2-3 times a day) but it is a subcutaneous injection (insulin needle) so it wouldn't be THAT bad.
    Some of this info may be bunk, it is just the 'underground juicer' heresy type gossip; and I have not even been keeping up with that for a good year now.
  • ...the huge jaw and sausage finger look - while worrying about heart explosions, there's HGH.

    For those that use the keyboard and don't professionally wrestle, there's Ask Slashdot.

  • Lilly [lilly.com] makes a product called Humatrope [humatrope.com] that's essentially a genetically-engineered analog to HGH. Their product site has some decent info on the conditions it's intended to treat, most of which applies to HGH as well.
  • I am not anything close to an American Football fan, but I do know that former NFL'er Lyle Alzado died from Cancer. It was said that his cancer was caused by using HGH, along with many other anabolics.

    Of course, he was probably taking enough to kill a race horse. From what I have both read and heard, this stuff makes bone tissue grow, not just muscle tissue. Who the heck knows what it does to your kidneys.
  • I get a lot of spam selling Penis Enlarging Pumps. Supposedly they add 3-4" to your cock, help you pick up chicks, etc. etc. Does anyone really know any good articles about this? Is it dangerous? The fact that it's being sold through spam is enough to give me pause, but I want to know if there are any legitimate uses for a 10" pecker.
  • The pituitary gland secretes it and it backs off by about 25% every 10 years starting in your late 20s.
    It helps reduce bodyfat, increase vascularity, and with testosterone it will also increase lean body mass (will not do so on its own).
    Any growth from it largely comes from its stimulation of IGF-1 (insulin like growth factors).
    Bodybuilders mix it with insulin to get to the freakish size that they are now (not to mention it helps if your body already isn't very good at producing myostatin).

    In obvious terms, the spam is worthless and you shouldn't bother with it.
    Reasons why:
    1) HGH is expensive, but WAY more expensive through these clincs that are spamming
    2) worse yet, HGH is frequently faked, or people try to sell precursors or things that will stimulate natural production - they don't work (although IV glutamine has shown some response - but not oral).
    3) once you start using outside sources of HGH, your body will shut down its own production, and for the most part, once it shuts down, it isn't coming back.
    4) the side effects of giganticism are largely falsehoods - you would need HUGE doses of HGH for a long time, and your growht plates would need to not be fused yet - so when you are 10 and hit the HGH hard, then you will be tall and grow caveman-like features, but otherwise, you aren't likely going to.
    The GH gut (large protruding abdomen) is argued to be a falsehood as well, but there seems to be fighting on either side how much that is true. It seems that the gut (seen in nearly all bodybuilders) is more likely from overfeeding and high levels of other hormones in the system, as well as torn abdominal supporting structures).

    If you want to improve your body health and shape, you are far better off (in terms of health, long term side effects, and cost) just buying fish oils.
    Fish oil is nearly all Omega-3s. The regular diet of the average person is high in Omega-6 but low in Omega-3 - raise up the latter and you will improve your insulin sensitivity as well as increase testosterone production, not to mention increased permiability in the cell membrane.

    I can go on and on...

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