cfsmp3 asks: "I have been asked to define the infrastructure for the email system for a huge company, which fed up of Exchange, wants to replace their entire system with something non-Microsoft. I have done this before, but not for anything of this scale. Suppose you are given a chance to build from scratch an email system that has to support around one million accounts. Some corporate, some personal, some free. POP, IMAP, webmail, etc are requirements. The system must scale perfectly, 99.9% uptime is expected... where would you start?"
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